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Jackson Laboratory gene knockout mouse model 441 alb cre mice
Gene Knockout Mouse Model 441 Alb Cre Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mouse+models/gene+mice+ppif+targeted/pm42269771-181-7-17
Average 86 stars, based on 1 article reviews
gene knockout mouse model 441 alb cre mice - by Bioz Stars, 2026-09
86/100 stars

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Article Title: TMPO promotes cellular dissemination and metastasis in circulating tumor cells
Article Snippet: The genetically engineered mouse models (GEMMs) used in this study have been described previously ( – , ) and the multi-allelic strains are available in the Jackson laboratory (Resource Tables R1 and R2): (i) NP mice, for Nkx3.1 CreERT2/+ ;Pten flox/flox ; R26R-CAG- LSL-EYFP/+ ( ); (ii) NPM mice, for Nkx3.1 CreERT2/+ ;Pten flox/flox ; Hi-MYC; R26R-CAG- LSL-EYFP/+ ( ); (iii) NPp53 mice, for Nkx3.1 CreERT2/+ ; Pten flox/flox ; Trp53 flox/flox ; R26R-CAG- LSL-EYFP/+ ( ); and (iv) NPK mice, for Nkx3.1 CreERT2/+ ; Pten flox/flox ; Kras lsl-G12D/+ ; R26R-CAG- LSL-EYFP/+ ( ).

Article Title: Extracellular matrix stiffness orchestrates NETs formation and mTOR-Driven metabolic reprogramming in lung cancer.
Article Snippet: Lung cancer is strongly associated with increased extracellular matrix (ECM) stiffness, which correlates with poor patient prognosis.. Our study reveals that high-stiffness tumor niches exhibit significant upregulation of neutrophil extracellular traps (NETs), which enhance the Warburg effect and promote tumor cell proliferation.. Using atomic force microscopy (AFM) and multi-immunofluorescence staining (mIF), we demonstrated a spatial correlation between NETs formation and localized ECM stiffness in lung cancer tissues.

Article Title: Dax1 in AgRP neurons regulates thermogenesis via GR-HDAC3-mediated CRFR1 suppression.
Article Snippet: Animals The following mouse models were applied in this study: Dax1f/f (The Jackson Laboratory, strain #007006) [17], Npy-hrGFP+ (The Jackson Laboratory, strain #006417) [42], Nkx2.1-Cre (The Jackson Laboratory, strain #008661) [18], Agrp-IRES-Cre (The Jackson Laboratory, strain #012899) [19].

Article Title: Next-generation all-in-one CRISPR/Cas9 multiply-edited CD30CAR-T cells: Potency despite risk of translocations
Article Snippet: R. Stripecke obtained research funding of The Jackson Laboratory to develop mouse models using the NSG-DKO strain.

Article Title: Next-generation all-in-one CRISPR/Cas9 multiply-edited CD30CAR-T cells: Potency despite risk of translocations
Article Snippet: R. Stripecke obtained research funding from The Jackson Laboratory to develop mouse models using the NSG-DKO strain.

Article Title: Alternating Hemiplegia of Childhood and ATP1A3 -Related Diseases
Article Snippet: Given the limited number of patients, lack of comprehensive natural history studies, and sparse postmortem data, mouse models are instrumental in bridging the knowledge gap. e26 The Jackson Laboratory Rare Disease Translational Center serves as a repository for existing mouse models and collaborates with rare disease foundations to develop new models and conduct preclinical therapeutic tests.

Article Title: Therapy‐Induced ECM Remodeling Creates a Transient Immune Barrier in Residual Melanoma
Article Snippet: Mouse Models: C57BL/6J mice were purchased from The Jackson Laboratory and bred in-house.

Genetically Modified:

Article Title: TREM2 and APOE are dispensable for microglial clearance of dying neurons revealed by in vivo imaging
Article Snippet: .. In this study, we used several genetically modified mouse models, including Trem2 KO (JAX stock#027197) (2-4 months old), Apoe KO (JAX stock #002052) (2-4 months old), 5xFAD (JAX stock#34840) (8-10 months old), and CX3CR1-GFP (JAX stock#005582) (2-4 months old). ..



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